Research progress on SARS, MERS and COVID-19 coronavirus

beta-Coronavirus(beta-CoV) contains a type of related viruses that can cause human respiratory infections.It is widespread in nature and can cause serious harm to humans or animals. The infection of the virus has the characteristics of high infectivity, wide epidemic, strong suddenness, and without effective preventive medication, which imposes a large medical burden on the country and patients. This review briefly summarizes the epidemic situation, transmission route, pathogenicity, pathogenesis and latest progress in drugs and vaccines of acute respiratory syndrome coronavirus(SARS-CoV), Middle East respiratory syndrome coronavirus(MERS-CoV) and the severe acute respiratory syndrome coronavirus 2(SARS-COV-2) since December 2019.